Unemployment Rate in Macon County, MO was 4.00% in March of 2024, according to the United States Federal Reserve. Historically, Unemployment Rate in Macon County, MO reached a record high of 17.60 in March of 1990 and a record low of 1.80 in September of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Macon County, MO - last updated from the United States Federal Reserve on May of 2024.